                         SEQUENCE LISTING



<110>  Boyle, Bryan J

      Mize, Nancy K

      Arterburn, Matthew C

      Yeung, George 

      Tang, Y. Tom

      Zhou, Ping 

      Liu, Chenghua 

      Asundi, Vinod 

      Ghosh, Malabika 

      Wang, JianRui 

      Song, Yong 

      Sjaastad, Michael 



<120>  Methods and Materials Relating to Neurotrimin-like Polypeptides and Polynucleotides



<130>  HYS-17CP3/PCT



<140>  Not Yet Assigned

<141>  2003-05-14



<150>  US 10/160,521

<151>  2002-05-29



<150>  PCT/US01/03651

<151>  2001-02-02



<150>  US 09/632,085

<151>  2000-08-02



<150>  US 09/496,914

<151>  2000-02-03



<150>  Not Yet Assigned

<151>  2002-09-27



<150>  PCT/US01/08631

<151>  2001-03-30



<150>  US 09/649,167

<151>  2000-08-23



<150>  US 09/540,217

<151>  2000-03-31



<160>  31    



<170>  PatentIn version 3.1



<210>  1

<211>  398

<212>  DNA

<213>  Homo sapiens



<400>  1
tggggttgac atctatgagc ccctctacac tcagggggag accaaggtcc tgaagctgaa     60

gaacctgcgg ccccaggact atgccagcta cacctgccag gtgtctgtgc gtaacgtgtg    120

cggcatccca gacaaggcca tcaccttccg gctcaccaac accacggcac caccagccct    180

gaagctgtct gtgaacgaaa ctctggtggt gaaccctggg gagaatgtga cggtgcagtg    240

tctgctgaca ggcggtgatc ccctccccca gctgcagtgg tcccatgggc ctggcccact    300

gcccctgggt gctctggccc agggtggcac cctcagcatc ccttcagtgc aggcccggga    360

ctctggctac tacaactgca cagccaccaa caatgtgg                            398


<210>  2

<211>  1124

<212>  DNA

<213>  Homo sapiens



<400>  2
cccactaagt aggacatcag accggccgct actactgcag gctgaaacgg cgtgggggtg     60

tcgtcttaag tccatccgcg tggacgtgca gtacctggat gagccaatgc tgacggtgca    120

ccagacggtg agcgatgtgc gaggcaactt ctaccaggag aagacggtgt tcctgcgctg    180

tactgtcaac tccaacccac ctgcccgctt catctggaag cggggttccg ataccctatc    240

ccacagccag gacaatgggg ttgacatcta tgagcccctc tacactcagg gggagaccaa    300

ggtcctgaag ctgaagaacc tgcggcccca ggactatgcc agctacacct gccaggtgtc    360

tgtgcgtaac gtgtgcggca tcccagacaa ggccatcacc ttccggctca ccaacaccac    420

ggcaccacca gccctgaagc tgtctgtgaa cgaaactctg gtggtgaacc ctggggagaa    480

tgtgacggtg cagtgtctgc tgacaggcgg tgatcccctc ccccagctgc agtggtccca    540

tgggcctggc ccactgcccc tgggtgctct ggcccagggt ggcaccctca gcatcccttc    600

agtgcaggcc cgggactctg gctactacaa ctgcacagcc accaacaatg tgggcaaccc    660

tgccaagaag actgtcaacc tgctggtgcg atccatgaag aacgctacat tccagatcac    720

tcctgacgtg atcaaagaga gtgagaacat ccagctgggc caggacctga agctatcgtg    780

ccacgtggat gcagtgcccc aggagaaggt gacctaccag tggttcaaga atggcaagcc    840

ggcacgcatg tccaagcggc tgctggtgac ccgcaatgat cctgagctgc ccgcagtcac    900

cagcagccta gagctcattg acctgcactt cagtgactat ggcacctacc tgtgcatggc    960

ttctttccca ggggcacccg tgcccgacct cagcgtcgag gtcaacatct cctctgagac   1020

agtgccgccc accatcagtg tgcccaaggg tagggccgtg gtgaccgtgc gcgagggatc   1080

gcctgccgag ctgcaatgcg aggtgcgggg caagccgcgg ccgc                    1124


<210>  3

<211>  1699

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (171)..(1547)

<223>  



<400>  3
tcttcgtcgc cgctctctct ctcacctctc agggaaaggg ggggacatag gggcgtcgcg     60

gggccccggc gaatgcgccc cccgccgcct ctcgggctgc gccgcctcac tatagggctc    120

gagcggccgc cgccggcagg tctcgcgggg atgaagcacc ggccgtgaag atg gag       176
                                                       Met Glu          
                                                       1                

gtg acc tgc ctt cta ctt ctg gcg ctg atc ccc ttc cac tgc cgg gga      224
Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys Arg Gly         
        5                   10                  15                      

caa gga gtc tac gct cca gcc cag gcg cag atc gtg cat gcg ggc cag      272
Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala Gly Gln         
    20                  25                  30                          

gca tgt gtg gtg aaa gag gac aat atc agc gag cgt gtc tac acc atc      320
Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr Thr Ile         
35                  40                  45                  50          

cgg gag ggg gac acc ctc atg ctg cag tgc ctt gta aca ggg cac cct      368
Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly His Pro         
                55                  60                  65              

cga ccc cag gta cgg tgg acc aag acg gca ggt agc gcc tcg gac aag      416
Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys         
            70                  75                  80                  

ttc cag gag aca tcg gtg ttc aac gag acg ctg cgc atc gag cgt att      464
Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile         
        85                  90                  95                      

gca cgc acg cag ggc ggc cgc tac tac tgc aag gct gag aac ggc gtg      512
Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn Gly Val         
    100                 105                 110                         

ggg gtg ccg gcc atc aag tcc atc cgc gtg gac gtg cag tac ctg gat      560
Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr Leu Asp         
115                 120                 125                 130         

gag cca atg ctg acg gtg cac cag acg gtg agc gat gtg cga ggc aac      608
Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg Gly Asn         
                135                 140                 145             

ttc tac cag gag aag acg gtg ttc ctg cgc tgt act gtc aac tcc aac      656
Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser Asn         
            150                 155                 160                 

cca cct gcc cgc ttc atc tgg aag cgg ggt tcc gat acc cta tcc cac      704
Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser His         
        165                 170                 175                     

agc cag gac aat ggg gtt gac atc tat gag ccc ctc tac act cag ggg      752
Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln Gly         
    180                 185                 190                         

gag acc aag gtc ctg aag ctg aag aac ctg cgg ccc cag gac tat gcc      800
Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr Ala         
195                 200                 205                 210         

agc tac acc tgc cag gtg tct gtg cgt aac gtg tgc ggc atc cca gac      848
Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile Pro Asp         
                215                 220                 225             

aag gcc atc acc ttc cgg ctc acc aac acc acg gca cca cca gcc ctg      896
Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro Ala Leu         
            230                 235                 240                 

aag ctg tct gtg aac gaa act ctg gtg gtg aac cct ggg gag aat gtg      944
Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu Asn Val         
        245                 250                 255                     

acg gtg cag tgt ctg ctg aca ggc ggt gat ccc ctc ccc cag ctg cag      992
Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln Leu Gln         
    260                 265                 270                         

tgg tcc cat ggg cct ggc cca ctg ccc ctg ggt gct ctg gcc cag ggt     1040
Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala Gln Gly         
275                 280                 285                 290         

ggc acc ctc agc atc cct tca gtg cag gcc cgg gac tct ggc tac tac     1088
Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr Tyr         
                295                 300                 305             

aac tgc aca gcc acc aac aat gtg ggc aac cct gcc aag aag act gtc     1136
Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr Val         
            310                 315                 320                 

aac ctg ctg gtg cga tcc atg aag aac gct aca ttc cag atc act cct     1184
Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile Thr Pro         
        325                 330                 335                     

gac gtg atc aaa gag agt gag aac atc cag ctg ggc cag gac ctg aag     1232
Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp Leu Lys         
    340                 345                 350                         

cta tcg tgc cac gtg gat gca gtg ccc cag gag aag gtg acc tac cag     1280
Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr Tyr Gln         
355                 360                 365                 370         

tgg ttc aag aat ggc aag ccg gca cgc atg tcc aag cgg ctg ctg gtg     1328
Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu Leu Val         
                375                 380                 385             

acc cgc aat gat cct gag ctg ccc gca gtc acc agc agc cta gag ctc     1376
Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu Glu Leu         
            390                 395                 400                 

att gac ctg cac ttc agt gac tat ggc acc tac ctg tgc atg gct tct     1424
Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met Ala Ser         
        405                 410                 415                     

ttc cca ggg gca ccc gtg ccc gac ctc agc gtc gag gtc aac atc tcc     1472
Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn Ile Ser         
    420                 425                 430                         

tct gag aca ggt ggg cag ctg gag ggg cac tgc gga aat gtg agg ggg     1520
Ser Glu Thr Gly Gly Gln Leu Glu Gly His Cys Gly Asn Val Arg Gly         
435                 440                 445                 450         

gtg gag agg ccc aca gac agg agg tag tggggaggca acggcttggg           1567
Val Glu Arg Pro Thr Asp Arg Arg                                         
                455                                                     

aaagggaagc cagagtgagg aggccaccac ttgttcatgc cacgtgcttt tattgagtcc   1627

ctgttaatat gccaggcact gtgctaggtc ctggggtaga gtggtgggca aaacaggctc   1687

agaacaacga ca                                                       1699


<210>  4

<211>  458

<212>  PRT

<213>  Homo sapiens



<400>  4

Met Glu Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys 
1               5                   10                  15      


Arg Gly Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala 
            20                  25                  30          


Gly Gln Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr 
        35                  40                  45              


Thr Ile Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly 
    50                  55                  60                  


His Pro Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser 
65                  70                  75                  80  


Asp Lys Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu 
                85                  90                  95      


Arg Ile Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn 
            100                 105                 110         


Gly Val Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr 
        115                 120                 125             


Leu Asp Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg 
    130                 135                 140                 


Gly Asn Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn 
145                 150                 155                 160 


Ser Asn Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu 
                165                 170                 175     


Ser His Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr 
            180                 185                 190         


Gln Gly Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp 
        195                 200                 205             


Tyr Ala Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile 
    210                 215                 220                 


Pro Asp Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro 
225                 230                 235                 240 


Ala Leu Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu 
                245                 250                 255     


Asn Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln 
            260                 265                 270         


Leu Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala 
        275                 280                 285             


Gln Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly 
    290                 295                 300                 


Tyr Tyr Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys 
305                 310                 315                 320 


Thr Val Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile 
                325                 330                 335     


Thr Pro Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp 
            340                 345                 350         


Leu Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr 
        355                 360                 365             


Tyr Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu 
    370                 375                 380                 


Leu Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu 
385                 390                 395                 400 


Glu Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met 
                405                 410                 415     


Ala Ser Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn 
            420                 425                 430         


Ile Ser Ser Glu Thr Gly Gly Gln Leu Glu Gly His Cys Gly Asn Val 
        435                 440                 445             


Arg Gly Val Glu Arg Pro Thr Asp Arg Arg 
    450                 455             


<210>  5

<211>  1377

<212>  DNA

<213>  Homo sapiens



<400>  5
atggaggtga cctgccttct acttctggcg ctgatcccct tccactgccg gggacaagga     60

gtctacgctc cagcccaggc gcagatcgtg catgcgggcc aggcatgtgt ggtgaaagag    120

gacaatatca gcgagcgtgt ctacaccatc cgggaggggg acaccctcat gctgcagtgc    180

cttgtaacag ggcaccctcg accccaggta cggtggacca agacggcagg tagcgcctcg    240

gacaagttcc aggagacatc ggtgttcaac gagacgctgc gcatcgagcg tattgcacgc    300

acgcagggcg gccgctacta ctgcaaggct gagaacggcg tgggggtgcc ggccatcaag    360

tccatccgcg tggacgtgca gtacctggat gagccaatgc tgacggtgca ccagacggtg    420

agcgatgtgc gaggcaactt ctaccaggag aagacggtgt tcctgcgctg tactgtcaac    480

tccaacccac ctgcccgctt catctggaag cggggttccg ataccctatc ccacagccag    540

gacaatgggg ttgacatcta tgagcccctc tacactcagg gggagaccaa ggtcctgaag    600

ctgaagaacc tgcggcccca ggactatgcc agctacacct gccaggtgtc tgtgcgtaac    660

gtgtgcggca tcccagacaa ggccatcacc ttccggctca ccaacaccac ggcaccacca    720

gccctgaagc tgtctgtgaa cgaaactctg gtggtgaacc ctggggagaa tgtgacggtg    780

cagtgtctgc tgacaggcgg tgatcccctc ccccagctgc agtggtccca tgggcctggc    840

ccactgcccc tgggtgctct ggcccagggt ggcaccctca gcatcccttc agtgcaggcc    900

cgggactctg gctactacaa ctgcacagcc accaacaatg tgggcaaccc tgccaagaag    960

actgtcaacc tgctggtgcg atccatgaag aacgctacat tccagatcac tcctgacgtg   1020

atcaaagaga gtgagaacat ccagctgggc caggacctga agctatcgtg ccacgtggat   1080

gcagtgcccc aggagaaggt gacctaccag tggttcaaga atggcaagcc ggcacgcatg   1140

tccaagcggc tgctggtgac ccgcaatgat cctgagctgc ccgcagtcac cagcagccta   1200

gagctcattg acctgcactt cagtgactat ggcacctacc tgtgcatggc ttctttccca   1260

ggggcacccg tgcccgacct cagcgtcgag gtcaacatct cctctgagac aggtgggcag   1320

ctggaggggc actgcggaaa tgtgaggggg gtggagaggc ccacagacag gaggtag      1377


<210>  6

<211>  2196

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (171)..(1931)

<223>  



<400>  6
tcttcgtcgc cgctctctct ctcacctctc agggaaaggg ggggacatag gggcgtcgcg     60

gggccccggc gaatgcgccc cccgccgcct ctcgggctgc gccgcctcac tatagggctc    120

gagcggccgc cgccggcagg tctcgcgggg atgaagcacc ggccgtgaag atg gag       176
                                                       Met Glu          
                                                       1                

gtg acc tgc ctt cta ctt ctg gcg ctg atc ccc ttc cac tgc cgg gga      224
Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys Arg Gly         
        5                   10                  15                      

caa gga gtc tac gct cca gcc cag gcg cag atc gtg cat gcg ggc cag      272
Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala Gly Gln         
    20                  25                  30                          

gca tgt gtg gtg aaa gag gac aat atc agc gag cgt gtc tac acc atc      320
Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr Thr Ile         
35                  40                  45                  50          

cgg gag ggg gac acc ctc atg ctg cag tgc ctt gta aca ggg cac cct      368
Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly His Pro         
                55                  60                  65              

cga ccc cag gta cgg tgg acc aag acg gca ggt agc gcc tcg gac aag      416
Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys         
            70                  75                  80                  

ttc cag gag aca tcg gtg ttc aac gag acg ctg cgc atc gag cgt att      464
Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile         
        85                  90                  95                      

gca cgc acg cag ggc ggc cgc tac tac tgc aag gct gag aac ggc gtg      512
Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn Gly Val         
    100                 105                 110                         

ggg gtg ccg atc aag tcc atc cgc gtg gac gtg cag tac ctg gat gag      560
Gly Val Pro Ile Lys Ser Ile Arg Val Asp Val Gln Tyr Leu Asp Glu         
115                 120                 125                 130         

cca atg ctg acg gtg cac cag acg gtg agc gat gtg cga ggc aac ttc      608
Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg Gly Asn Phe         
                135                 140                 145             

tac cag gag aag acg gtg ttc ctg cgc tgt act gtc aac tcc aac cca      656
Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser Asn Pro         
            150                 155                 160                 

cct gcc cgc ttc atc tgg aag cgg ggt tcc gat acc cta tcc cac agc      704
Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser His Ser         
        165                 170                 175                     

cag gac aat ggg gtt gac atc tat gag ccc ctc tac act cag ggg gag      752
Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln Gly Glu         
    180                 185                 190                         

acc aag gtc ctg aag ctg aag aac ctg cgg ccc cag gac tat gcc agc      800
Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr Ala Ser         
195                 200                 205                 210         

tac acc tgc cag gtg tct gtg cgt aac gtg tgc ggc atc cca gac aag      848
Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile Pro Asp Lys         
                215                 220                 225             

gcc atc acc ttc cgg ctc acc aac acc acg gca cca cca gcc ctg aag      896
Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro Ala Leu Lys         
            230                 235                 240                 

ctg tct gtg aac gaa act ctg gtg gtg aac cct ggg gag aat gtg acg      944
Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu Asn Val Thr         
        245                 250                 255                     

gtg cag tgt ctg ctg aca ggc ggt gat ccc ctc ccc cag ctg cag tgg      992
Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln Leu Gln Trp         
    260                 265                 270                         

tcc cat ggg cct ggc cca ctg ccc ctg ggt gct ctg gcc cag ggt ggc     1040
Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala Gln Gly Gly         
275                 280                 285                 290         

acc ctc agc atc cct tca gtg cag gcc cgg gac tct ggc tac tac aac     1088
Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr Tyr Asn         
                295                 300                 305             

tgc aca gcc acc aac aat gtg ggc aac cct gcc aag aag act gtc aac     1136
Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr Val Asn         
            310                 315                 320                 

ctg ctg gtg cga tcc atg aag aac gct aca ttc cag atc act cct gac     1184
Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile Thr Pro Asp         
        325                 330                 335                     

gtg atc aaa gag agt gag aac atc cag ctg ggc cag gac ctg aag cta     1232
Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp Leu Lys Leu         
    340                 345                 350                         

tcg tgc cac gtg gat gca gtg ccc cag gag aag gtg acc tac cag tgg     1280
Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr Tyr Gln Trp         
355                 360                 365                 370         

ttc aag aat ggc aag ccg gca cgc atg tcc aag cgg ctg ctg gtg acc     1328
Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu Leu Val Thr         
                375                 380                 385             

cgc aat gat cct gag ctg ccc gca gtc acc agc agc cta gag ctc att     1376
Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu Glu Leu Ile         
            390                 395                 400                 

gac ctg cac ttc agt gac tat ggc acc tac ctg tgc atg gct tct ttc     1424
Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met Ala Ser Phe         
        405                 410                 415                     

cca ggg gca ccc gtg ccc gac ctc agc gtc gag gtc aac atc tcc tct     1472
Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn Ile Ser Ser         
    420                 425                 430                         

gag aca gtg ccg ccc acc atc agt gtg ccc aag ggt agg gcc gtg gtg     1520
Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg Ala Val Val         
435                 440                 445                 450         

acc gtg cgc gag gga tcg cct gcc gag ctg caa tgc gag gtg cgg ggc     1568
Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu Val Arg Gly         
                455                 460                 465             

aag ccg cgg ccg cca gtg ctc tgg tcc cgc gtg gac aag gag gct gca     1616
Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys Glu Ala Ala         
            470                 475                 480                 

ctg ctg ccc tcg ggg ctg ccc ctg gag gag act ccg gac ggg aag ctg     1664
Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp Gly Lys Leu         
        485                 490                 495                     

cgg ctg gag cga gtg agc cga gac atg agc ggg acc tac cgc tgc cag     1712
Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr Arg Cys Gln         
    500                 505                 510                         

acg gcc cgc tat aat ggc ttc aac gtg cgc ccc cgt gag gcc cag gtg     1760
Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu Ala Gln Val         
515                 520                 525                 530         

cag ctg aac gtg cag tgt gag tcc acc acg cca ccc gga cta cct tcc     1808
Gln Leu Asn Val Gln Cys Glu Ser Thr Thr Pro Pro Gly Leu Pro Ser         
                535                 540                 545             

cag ctt tcc ttc tgg ctc cca gcc ggc ctg tcc cct ctt cat cct ctc     1856
Gln Leu Ser Phe Trp Leu Pro Ala Gly Leu Ser Pro Leu His Pro Leu         
            550                 555                 560                 

acc cac ccc agt cca acc aaa ccc cac cag cta ctc ctg ata ccc cta     1904
Thr His Pro Ser Pro Thr Lys Pro His Gln Leu Leu Leu Ile Pro Leu         
        565                 570                 575                     

atg ctc ctt gac agc ccc atg ctg tag gacacggagg tctgtgttct           1951
Met Leu Leu Asp Ser Pro Met Leu                                         
    580                 585                                             

ttgctccatt tcatcaagta tctcccatct tcattttcag ggacccggtg aacaaaaaaa   2011

aaattacttg attttgccag gtggaaatgg gattttgaag gaggaggaag gacactcaag   2071

ggaaacactg tctgataaca agatgatgaa aattaccacc atgtgccaaa cactgttcta   2131

ggagttttaa ggcactaact cattgaactt cccctcgtgc cgaattcttg gcctcgaggg   2191

gccaa                                                               2196


<210>  7

<211>  586

<212>  PRT

<213>  Homo sapiens



<400>  7

Met Glu Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys 
1               5                   10                  15      


Arg Gly Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala 
            20                  25                  30          


Gly Gln Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr 
        35                  40                  45              


Thr Ile Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly 
    50                  55                  60                  


His Pro Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser 
65                  70                  75                  80  


Asp Lys Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu 
                85                  90                  95      


Arg Ile Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn 
            100                 105                 110         


Gly Val Gly Val Pro Ile Lys Ser Ile Arg Val Asp Val Gln Tyr Leu 
        115                 120                 125             


Asp Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg Gly 
    130                 135                 140                 


Asn Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser 
145                 150                 155                 160 


Asn Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser 
                165                 170                 175     


His Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln 
            180                 185                 190         


Gly Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr 
        195                 200                 205             


Ala Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile Pro 
    210                 215                 220                 


Asp Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro Ala 
225                 230                 235                 240 


Leu Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu Asn 
                245                 250                 255     


Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln Leu 
            260                 265                 270         


Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala Gln 
        275                 280                 285             


Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr 
    290                 295                 300                 


Tyr Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr 
305                 310                 315                 320 


Val Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile Thr 
                325                 330                 335     


Pro Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp Leu 
            340                 345                 350         


Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr Tyr 
        355                 360                 365             


Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu Leu 
    370                 375                 380                 


Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu Glu 
385                 390                 395                 400 


Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met Ala 
                405                 410                 415     


Ser Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn Ile 
            420                 425                 430         


Ser Ser Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg Ala 
        435                 440                 445             


Val Val Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu Val 
    450                 455                 460                 


Arg Gly Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys Glu 
465                 470                 475                 480 


Ala Ala Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp Gly 
                485                 490                 495     


Lys Leu Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr Arg 
            500                 505                 510         


Cys Gln Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu Ala 
        515                 520                 525             


Gln Val Gln Leu Asn Val Gln Cys Glu Ser Thr Thr Pro Pro Gly Leu 
    530                 535                 540                 


Pro Ser Gln Leu Ser Phe Trp Leu Pro Ala Gly Leu Ser Pro Leu His 
545                 550                 555                 560 


Pro Leu Thr His Pro Ser Pro Thr Lys Pro His Gln Leu Leu Leu Ile 
                565                 570                 575     


Pro Leu Met Leu Leu Asp Ser Pro Met Leu 
            580                 585     


<210>  8

<211>  1761

<212>  DNA

<213>  Homo sapiens



<400>  8
atggaggtga cctgccttct acttctggcg ctgatcccct tccactgccg gggacaagga     60

gtctacgctc cagcccaggc gcagatcgtg catgcgggcc aggcatgtgt ggtgaaagag    120

gacaatatca gcgagcgtgt ctacaccatc cgggaggggg acaccctcat gctgcagtgc    180

cttgtaacag ggcaccctcg accccaggta cggtggacca agacggcagg tagcgcctcg    240

gacaagttcc aggagacatc ggtgttcaac gagacgctgc gcatcgagcg tattgcacgc    300

acgcagggcg gccgctacta ctgcaaggct gagaacggcg tgggggtgcc gatcaagtcc    360

atccgcgtgg acgtgcagta cctggatgag ccaatgctga cggtgcacca gacggtgagc    420

gatgtgcgag gcaacttcta ccaggagaag acggtgttcc tgcgctgtac tgtcaactcc    480

aacccacctg cccgcttcat ctggaagcgg ggttccgata ccctatccca cagccaggac    540

aatggggttg acatctatga gcccctctac actcaggggg agaccaaggt cctgaagctg    600

aagaacctgc ggccccagga ctatgccagc tacacctgcc aggtgtctgt gcgtaacgtg    660

tgcggcatcc cagacaaggc catcaccttc cggctcacca acaccacggc accaccagcc    720

ctgaagctgt ctgtgaacga aactctggtg gtgaaccctg gggagaatgt gacggtgcag    780

tgtctgctga caggcggtga tcccctcccc cagctgcagt ggtcccatgg gcctggccca    840

ctgcccctgg gtgctctggc ccagggtggc accctcagca tcccttcagt gcaggcccgg    900

gactctggct actacaactg cacagccacc aacaatgtgg gcaaccctgc caagaagact    960

gtcaacctgc tggtgcgatc catgaagaac gctacattcc agatcactcc tgacgtgatc   1020

aaagagagtg agaacatcca gctgggccag gacctgaagc tatcgtgcca cgtggatgca   1080

gtgccccagg agaaggtgac ctaccagtgg ttcaagaatg gcaagccggc acgcatgtcc   1140

aagcggctgc tggtgacccg caatgatcct gagctgcccg cagtcaccag cagcctagag   1200

ctcattgacc tgcacttcag tgactatggc acctacctgt gcatggcttc tttcccaggg   1260

gcacccgtgc ccgacctcag cgtcgaggtc aacatctcct ctgagacagt gccgcccacc   1320

atcagtgtgc ccaagggtag ggccgtggtg accgtgcgcg agggatcgcc tgccgagctg   1380

caatgcgagg tgcggggcaa gccgcggccg ccagtgctct ggtcccgcgt ggacaaggag   1440

gctgcactgc tgccctcggg gctgcccctg gaggagactc cggacgggaa gctgcggctg   1500

gagcgagtga gccgagacat gagcgggacc taccgctgcc agacggcccg ctataatggc   1560

ttcaacgtgc gcccccgtga ggcccaggtg cagctgaacg tgcagtgtga gtccaccacg   1620

ccacccggac taccttccca gctttccttc tggctcccag ccggcctgtc ccctcttcat   1680

cctctcaccc accccagtcc aaccaaaccc caccagctac tcctgatacc cctaatgctc   1740

cttgacagcc ccatgctgta g                                             1761


<210>  9

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  9

Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr Tyr Asn 
1               5                   10                  15      


Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr Val Asn 
            20                  25                  30          


Leu Leu Val Arg 
        35      


<210>  10

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  10

Leu Arg Cys Thr Val Asn Ser Asn Pro Pro Ala Arg Phe Ile Trp Lys 
1               5                   10                  15      


Arg Gly Ser Asp Thr Leu Ser His 
            20                  


<210>  11

<211>  18

<212>  PRT

<213>  Homo sapiens



<400>  11

Met Glu Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys 
1               5                   10                  15      


Arg Gly 
        


<210>  12

<211>  440

<212>  PRT

<213>  Homo sapiens



<400>  12

Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala Gly Gln 
1               5                   10                  15      


Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr Thr Ile 
            20                  25                  30          


Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly His Pro 
        35                  40                  45              


Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys 
    50                  55                  60                  


Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile 
65                  70                  75                  80  


Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn Gly Val 
                85                  90                  95      


Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr Leu Asp 
            100                 105                 110         


Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg Gly Asn 
        115                 120                 125             


Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser Asn 
    130                 135                 140                 


Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser His 
145                 150                 155                 160 


Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln Gly 
                165                 170                 175     


Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr Ala 
            180                 185                 190         


Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile Pro Asp 
        195                 200                 205             


Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro Ala Leu 
    210                 215                 220                 


Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu Asn Val 
225                 230                 235                 240 


Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln Leu Gln 
                245                 250                 255     


Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala Gln Gly 
            260                 265                 270         


Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr Tyr 
        275                 280                 285             


Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr Val 
    290                 295                 300                 


Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile Thr Pro 
305                 310                 315                 320 


Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp Leu Lys 
                325                 330                 335     


Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr Tyr Gln 
            340                 345                 350         


Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu Leu Val 
        355                 360                 365             


Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu Glu Leu 
    370                 375                 380                 


Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met Ala Ser 
385                 390                 395                 400 


Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn Ile Ser 
                405                 410                 415     


Ser Glu Thr Gly Gly Gln Leu Glu Gly His Cys Gly Asn Val Arg Gly 
            420                 425                 430         


Val Glu Arg Pro Thr Asp Arg Arg 
        435                 440 


<210>  13

<211>  568

<212>  PRT

<213>  Homo sapiens



<400>  13

Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala Gly Gln 
1               5                   10                  15      


Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr Thr Ile 
            20                  25                  30          


Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly His Pro 
        35                  40                  45              


Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys 
    50                  55                  60                  


Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile 
65                  70                  75                  80  


Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn Gly Val 
                85                  90                  95      


Gly Val Pro Ile Lys Ser Ile Arg Val Asp Val Gln Tyr Leu Asp Glu 
            100                 105                 110         


Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg Gly Asn Phe 
        115                 120                 125             


Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser Asn Pro 
    130                 135                 140                 


Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser His Ser 
145                 150                 155                 160 


Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln Gly Glu 
                165                 170                 175     


Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr Ala Ser 
            180                 185                 190         


Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile Pro Asp Lys 
        195                 200                 205             


Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro Ala Leu Lys 
    210                 215                 220                 


Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu Asn Val Thr 
225                 230                 235                 240 


Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln Leu Gln Trp 
                245                 250                 255     


Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala Gln Gly Gly 
            260                 265                 270         


Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr Tyr Asn 
        275                 280                 285             


Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr Val Asn 
    290                 295                 300                 


Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile Thr Pro Asp 
305                 310                 315                 320 


Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp Leu Lys Leu 
                325                 330                 335     


Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr Tyr Gln Trp 
            340                 345                 350         


Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu Leu Val Thr 
        355                 360                 365             


Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu Glu Leu Ile 
    370                 375                 380                 


Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met Ala Ser Phe 
385                 390                 395                 400 


Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn Ile Ser Ser 
                405                 410                 415     


Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg Ala Val Val 
            420                 425                 430         


Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu Val Arg Gly 
        435                 440                 445             


Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys Glu Ala Ala 
    450                 455                 460                 


Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp Gly Lys Leu 
465                 470                 475                 480 


Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr Arg Cys Gln 
                485                 490                 495     


Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu Ala Gln Val 
            500                 505                 510         


Gln Leu Asn Val Gln Cys Glu Ser Thr Thr Pro Pro Gly Leu Pro Ser 
        515                 520                 525             


Gln Leu Ser Phe Trp Leu Pro Ala Gly Leu Ser Pro Leu His Pro Leu 
    530                 535                 540                 


Thr His Pro Ser Pro Thr Lys Pro His Gln Leu Leu Leu Ile Pro Leu 
545                 550                 555                 560 


Met Leu Leu Asp Ser Pro Met Leu 
                565             


<210>  14

<211>  299

<212>  PRT

<213>  Homo sapiens



<400>  14

Pro Pro Ala Leu Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro 
1               5                   10                  15      


Gly Glu Asn Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu 
            20                  25                  30          


Pro Gln Leu Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala 
        35                  40                  45              


Leu Ala Gln Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp 
    50                  55                  60                  


Ser Gly Tyr Tyr Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala 
65                  70                  75                  80  


Lys Lys Thr Val Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe 
                85                  90                  95      


Gln Ile Thr Pro Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly 
            100                 105                 110         


Gln Asp Leu Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys 
        115                 120                 125             


Val Thr Tyr Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys 
    130                 135                 140                 


Arg Leu Leu Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser 
145                 150                 155                 160 


Ser Leu Glu Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu 
                165                 170                 175     


Cys Met Ala Ser Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu 
            180                 185                 190         


Val Asn Ile Ser Ser Glu Thr Gly Val Pro Pro Thr Ile Ser Val Pro 
        195                 200                 205             


Lys Gly Arg Ala Val Val Thr Val Arg Glu Gly Ser Pro Ala Glu Leu 
    210                 215                 220                 


Gln Cys Glu Val Arg Gly Lys Pro Arg Pro Pro Val Leu Trp Ser Arg 
225                 230                 235                 240 


Val Asp Lys Glu Ala Ala Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu 
                245                 250                 255     


Thr Pro Asp Gly Lys Leu Arg Leu Glu Arg Val Ser Arg Asp Met Ser 
            260                 265                 270         


Gly Thr Tyr Arg Cys Gln Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg 
        275                 280                 285             


Pro Arg Glu Ala Gln Val Gln Leu Asn Val Gln 
    290                 295                 


<210>  15

<211>  250

<212>  PRT

<213>  Rattus norvegicus



<400>  15

Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asn Arg Val Thr 
1               5                   10                  15      


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
            20                  25                  30          


Lys Trp Cys Leu Asp Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr 
        35                  40                  45              


Gln Tyr Ser Ile Glu Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
    50                  55                  60                  


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
65                  70                  75                  80  


His Leu Ile Val Gln Val Ser Pro Lys Ile Val Glu Ile Ser Ser Asp 
                85                  90                  95      


Ile Ser Ile Asn Glu Gly Asn Asn Ile Ser Leu Thr Cys Ile Ala Thr 
            100                 105                 110         


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Ile Ser Pro Lys Ala 
        115                 120                 125             


Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
    130                 135                 140                 


Arg Glu Gln Ser Gly Glu Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
145                 150                 155                 160 


Ala Pro Val Val Arg Arg Val Asn Val Thr Val Asn Tyr Pro Pro Tyr 
                165                 170                 175     


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
            180                 185                 190         


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Phe 
        195                 200                 205             


Lys Asp Asp Lys Arg Leu Val Glu Gly Lys Lys Gly Val Lys Val Glu 
    210                 215                 220                 


Asn Arg Pro Phe Leu Ser Arg Leu Thr Phe Phe Asn Val Ser Glu His 
225                 230                 235                 240 


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser 
                245                 250 


<210>  16

<211>  374

<212>  PRT

<213>  Homo sapiens



<400>  16

Pro Leu Ser Arg Thr Ser Asp Arg Pro Leu Leu Leu Gln Ala Glu Thr 
1               5                   10                  15      


Ala Trp Gly Cys Arg Leu Lys Ser Ile Arg Val Asp Val Gln Tyr Leu 
            20                  25                  30          


Asp Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg Gly 
        35                  40                  45              


Asn Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser 
    50                  55                  60                  


Asn Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser 
65                  70                  75                  80  


His Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln 
                85                  90                  95      


Gly Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr 
            100                 105                 110         


Ala Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile Pro 
        115                 120                 125             


Asp Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro Ala 
    130                 135                 140                 


Leu Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu Asn 
145                 150                 155                 160 


Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln Leu 
                165                 170                 175     


Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala Gln 
            180                 185                 190         


Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr 
        195                 200                 205             


Tyr Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr 
    210                 215                 220                 


Val Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile Thr 
225                 230                 235                 240 


Pro Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp Leu 
                245                 250                 255     


Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr Tyr 
            260                 265                 270         


Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu Leu 
        275                 280                 285             


Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu Glu 
    290                 295                 300                 


Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met Ala 
305                 310                 315                 320 


Ser Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn Ile 
                325                 330                 335     


Ser Ser Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg Ala 
            340                 345                 350         


Val Val Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu Val 
        355                 360                 365             


Arg Gly Lys Pro Arg Pro 
    370                 


<210>  17

<211>  3312

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (169)..(3036)

<223>  



<400>  17
ggtcgccgcc acctccgcct cttcagtctc ctggtcttcg tcgccgctct ctctctcacc     60

tctcagggaa agggggggac ataggggcgt cgcggggccc cggcgaatgc gccccccgcc    120

gcctctcggg ctgcgccgcc tcgcggggat gaagcaccgg ccgtgaag atg gag gtg     177
                                                     Met Glu Val        
                                                     1                  

acc tgc ctt cta ctt ctg gcg ctg atc ccc ttc cac tgc cgg gga caa      225
Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys Arg Gly Gln         
    5                   10                  15                          

gga gtc tac gct cca gcc cag gcg cag atc gtg cat gcg ggc cag gca      273
Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala Gly Gln Ala         
20                  25                  30                  35          

tgt gtg gtg aaa gag gac aat atc agc gag cgt gtc tac acc atc cgg      321
Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr Thr Ile Arg         
                40                  45                  50              

gag ggg gac acc ctc atg ctg cag tgc ctt gta aca ggg cac cct cga      369
Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly His Pro Arg         
            55                  60                  65                  

ccc cag gta cgg tgg acc aag acg gca ggt agc gcc tcg gac aag ttc      417
Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys Phe         
        70                  75                  80                      

cag gag aca tcg gtg ttc aac gag acg ctg cgc atc gag cgt att gca      465
Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile Ala         
    85                  90                  95                          

cgc acg cag ggc ggc cgc tac tac tgc aag gct gag aac ggc gtg ggg      513
Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn Gly Val Gly         
100                 105                 110                 115         

gtg ccg gcc atc aag tcc atc cgc gtg gac gtg cag tac ctg gat gag      561
Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr Leu Asp Glu         
                120                 125                 130             

cca atg ctg acg gtg cac cag acg gtg agc gat gtg cga ggc aac ttc      609
Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg Gly Asn Phe         
            135                 140                 145                 

tac cag gag aag acg gtg ttc ctg cgc tgt act gtc aac tcc aac cca      657
Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser Asn Pro         
        150                 155                 160                     

cct gcc cgc ttc atc tgg aag cgg ggt tcc gat acc cta tcc cac agc      705
Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser His Ser         
    165                 170                 175                         

cag gac aat ggg gtt gac atc tat gag ccc ctc tac act cag ggg gag      753
Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln Gly Glu         
180                 185                 190                 195         

acc aag gtc ctg aag ctg aag aac ctg cgg ccc cag gac tat gcc agc      801
Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr Ala Ser         
                200                 205                 210             

tac acc tgc cag gtg tct gtg cgt aac gtg tgc ggc atc cca gac aag      849
Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile Pro Asp Lys         
            215                 220                 225                 

gcc atc acc ttc cgg ctc acc aac acc acg gca cca cca gcc ctg aag      897
Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro Ala Leu Lys         
        230                 235                 240                     

ctg tct gtg aac gaa act ctg gtg gtg aac cct ggg gag aat gtg acg      945
Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu Asn Val Thr         
    245                 250                 255                         

gtg cag tgt ctg ctg aca ggc ggt gat ccc ctc ccc cag ctg cag tgg      993
Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln Leu Gln Trp         
260                 265                 270                 275         

tcc cat ggg cct ggc cca ctg ccc ctg ggt gct ctg gcc cag ggt ggc     1041
Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala Gln Gly Gly         
                280                 285                 290             

acc ctc agc atc cct tca gtg cag gcc cgg gac tct ggc tac tac aac     1089
Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr Tyr Asn         
            295                 300                 305                 

tgc aca gcc acc aac aat gtg ggc aac cct gcc aag aag act gtc aac     1137
Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr Val Asn         
        310                 315                 320                     

ctg ctg gtg cga tcc atg aag aac gct aca ttc cag atc act cct gac     1185
Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile Thr Pro Asp         
    325                 330                 335                         

gtg atc aaa gag agt gag aac atc cag ctg ggc cag gac ctg aag cta     1233
Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp Leu Lys Leu         
340                 345                 350                 355         

tcg tgc cac gtg gat gca gtg ccc cag gag aag gtg acc tac cag tgg     1281
Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr Tyr Gln Trp         
                360                 365                 370             

ttc aag aat ggc aag ccg gca cgc atg tcc aag cgg ctg ctg gtg acc     1329
Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu Leu Val Thr         
            375                 380                 385                 

cgc aat gat cct gag ctg ccc gca gtc acc agc agc cta gag ctc att     1377
Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu Glu Leu Ile         
        390                 395                 400                     

gac ctg cac ttc agt gac tat ggc acc tac ctg tgc atg gct tct ttc     1425
Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met Ala Ser Phe         
    405                 410                 415                         

cca ggg gca ccc gtg ccc gac ctc agc gtc gag gtc aac atc tcc tct     1473
Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn Ile Ser Ser         
420                 425                 430                 435         

gag aca gtg ccg ccc acc atc agt gtg ccc aag ggt agg gcc gtg gtg     1521
Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg Ala Val Val         
                440                 445                 450             

acc gtg cgc gag gga tcg cct gcc gag ctg caa tgc gag gtg cgg ggc     1569
Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu Val Arg Gly         
            455                 460                 465                 

aag ccg cgg ccg cca gtg ctc tgg tcc cgc gtg gac aag gag gct gca     1617
Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys Glu Ala Ala         
        470                 475                 480                     

ctg ctg ccc tcg ggg ctg ccc ctg gag gag act ccg gac ggg aag ctg     1665
Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp Gly Lys Leu         
    485                 490                 495                         

cgg ctg gag cga gtg agc cga gac atg agc ggg acc tac cgc tgc cag     1713
Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr Arg Cys Gln         
500                 505                 510                 515         

acg gcc cgc tat aat ggc ttc aac gtg cgc ccc cgt gag gcc cag gtg     1761
Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu Ala Gln Val         
                520                 525                 530             

cag ctg aac gtg cag ttc ccg ccg gag gtg gag ccc agt tcc cag gac     1809
Gln Leu Asn Val Gln Phe Pro Pro Glu Val Glu Pro Ser Ser Gln Asp         
            535                 540                 545                 

gtg cgc cag gcg ctg ggc cgg ccc gtg ctc ctg cgc tgc tcg ctg ctg     1857
Val Arg Gln Ala Leu Gly Arg Pro Val Leu Leu Arg Cys Ser Leu Leu         
        550                 555                 560                     

cga ggc agc ccc cag cgc atc gcc tcg gct gtg tgg cgt ttc aaa ggg     1905
Arg Gly Ser Pro Gln Arg Ile Ala Ser Ala Val Trp Arg Phe Lys Gly         
    565                 570                 575                         

cag ctg ctg ccg ccg ccg cct gtt gtt ccc gcc gcc gcc gag gcg ccg     1953
Gln Leu Leu Pro Pro Pro Pro Val Val Pro Ala Ala Ala Glu Ala Pro         
580                 585                 590                 595         

gat cac gcg gag ctg cgc ctc gac gcc gta act cgc gac agc agc ggc     2001
Asp His Ala Glu Leu Arg Leu Asp Ala Val Thr Arg Asp Ser Ser Gly         
                600                 605                 610             

agc tac gag tgc agc gtc tcc aac gat gtg ggc tcg gct gcc tgc ctc     2049
Ser Tyr Glu Cys Ser Val Ser Asn Asp Val Gly Ser Ala Ala Cys Leu         
            615                 620                 625                 

ttc cag gtc tcc gcc aaa gcc tac agc ccg gag ttt tac ttc gac acc     2097
Phe Gln Val Ser Ala Lys Ala Tyr Ser Pro Glu Phe Tyr Phe Asp Thr         
        630                 635                 640                     

ccc aac ccc acc cgc agc cac aag ctg tcc aag aac tac tcc tac gtg     2145
Pro Asn Pro Thr Arg Ser His Lys Leu Ser Lys Asn Tyr Ser Tyr Val         
    645                 650                 655                         

ctg cag tgg act cag agg gag ccc gac gct gtc gac cct gtg ctc aac     2193
Leu Gln Trp Thr Gln Arg Glu Pro Asp Ala Val Asp Pro Val Leu Asn         
660                 665                 670                 675         

tac aga ctc agc atc cgc cag ttg aac cag cac aat gcg gtg gtc aag     2241
Tyr Arg Leu Ser Ile Arg Gln Leu Asn Gln His Asn Ala Val Val Lys         
                680                 685                 690             

gcc atc ccg gtc cgg cgt gtg gag aag ggg cag ctg ctg gag tac atc     2289
Ala Ile Pro Val Arg Arg Val Glu Lys Gly Gln Leu Leu Glu Tyr Ile         
            695                 700                 705                 

ctg acc gat ctc cgt gtg ccc cac agc tat gag gtc cgc ctc aca ccc     2337
Leu Thr Asp Leu Arg Val Pro His Ser Tyr Glu Val Arg Leu Thr Pro         
        710                 715                 720                     

tat acc acc ttc ggg gct ggt gac atg gcc tcc cgc atc atc cac tac     2385
Tyr Thr Thr Phe Gly Ala Gly Asp Met Ala Ser Arg Ile Ile His Tyr         
    725                 730                 735                         

aca gag ccc atc aac tct ccg aac ctt tca gac aac acc tgc cac ttt     2433
Thr Glu Pro Ile Asn Ser Pro Asn Leu Ser Asp Asn Thr Cys His Phe         
740                 745                 750                 755         

gag gat gag aag atc tgt ggc tat acc cag gac ctg aca gac aac ttt     2481
Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr Asp Asn Phe         
                760                 765                 770             

gac tgg acg cgg cag aat gcc ctc acc cag aac ccc aaa cgc tcc ccc     2529
Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys Arg Ser Pro         
            775                 780                 785                 

aac act ggt ccc ccc acc gac ata agt ggc acc cct gag ggc tac tac     2577
Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu Gly Tyr Tyr         
        790                 795                 800                     

atg ttc atc gag aca tcg agg cct cgg gag ctg ggg gac cgt gca agg     2625
Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp Arg Ala Arg         
    805                 810                 815                         

tta gtg agt ccc ctc tac aat gcc agc gcc aag ttc tac tgt gtc tcc     2673
Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Tyr Cys Val Ser         
820                 825                 830                 835         

ttc ttc tac cac atg tac ggg aaa cac atc ggc tcc ctc aac ctc ctg     2721
Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu Asn Leu Leu         
                840                 845                 850             

gtg cgg tcc cgg aac aaa ggg gct ctg gac acg cac gcc tgg tct ctc     2769
Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala Trp Ser Leu         
            855                 860                 865                 

agt ggc aat aag ggc aat gtg tgg cag cag gcc cat gtg ccc atc agc     2817
Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val Pro Ile Ser         
        870                 875                 880                     

ccc agt ggg ccc ttc cag att att ttt gag ggg gtt cga ggc ccg ggc     2865
Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg Gly Pro Gly         
    885                 890                 895                         

tac ctg ggg gat att gcc ata gat gac gtc aca ctg aag aag ggg gag     2913
Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys Lys Gly Glu         
900                 905                 910                 915         

tgt ccc cgg aag cag acg gat ccc aat aaa gtg gtg gtg atg ccg ggc     2961
Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Val Val Val Met Pro Gly         
                920                 925                 930             

agt gga gcc ccc tgc cag tcc agc cca cag ctg tgg ggg ccc atg gcc     3009
Ser Gly Ala Pro Cys Gln Ser Ser Pro Gln Leu Trp Gly Pro Met Ala         
            935                 940                 945                 

atc ttc ctc ttg gcg ttg cag aga tga tgagagctgt gtggccaccc           3056
Ile Phe Leu Leu Ala Leu Gln Arg                                         
        950                 955                                         

ccccaacctt gcccccggca caccaaagtg tccacattgt accaaagact gacccccgcc   3116

agctggggtg cccaggggca gggccggccc gccagggagg gggcctgcat tggctgcaag   3176

gatgagcaga gaacaaggac agaggccagg cactgaggcc ctggagacag ctgttccact   3236

tgcacacacg cacacactca tgctcacaca cacagagata tattaaagca caagtttcta   3296

tctgaaaaaa aaaaaa                                                   3312


<210>  18

<211>  955

<212>  PRT

<213>  Homo sapiens



<400>  18

Met Glu Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys 
1               5                   10                  15      


Arg Gly Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala 
            20                  25                  30          


Gly Gln Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr 
        35                  40                  45              


Thr Ile Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly 
    50                  55                  60                  


His Pro Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser 
65                  70                  75                  80  


Asp Lys Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu 
                85                  90                  95      


Arg Ile Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn 
            100                 105                 110         


Gly Val Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr 
        115                 120                 125             


Leu Asp Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg 
    130                 135                 140                 


Gly Asn Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn 
145                 150                 155                 160 


Ser Asn Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu 
                165                 170                 175     


Ser His Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr 
            180                 185                 190         


Gln Gly Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp 
        195                 200                 205             


Tyr Ala Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile 
    210                 215                 220                 


Pro Asp Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro 
225                 230                 235                 240 


Ala Leu Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu 
                245                 250                 255     


Asn Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln 
            260                 265                 270         


Leu Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala 
        275                 280                 285             


Gln Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly 
    290                 295                 300                 


Tyr Tyr Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys 
305                 310                 315                 320 


Thr Val Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile 
                325                 330                 335     


Thr Pro Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp 
            340                 345                 350         


Leu Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr 
        355                 360                 365             


Tyr Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu 
    370                 375                 380                 


Leu Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu 
385                 390                 395                 400 


Glu Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met 
                405                 410                 415     


Ala Ser Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn 
            420                 425                 430         


Ile Ser Ser Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg 
        435                 440                 445             


Ala Val Val Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu 
    450                 455                 460                 


Val Arg Gly Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys 
465                 470                 475                 480 


Glu Ala Ala Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp 
                485                 490                 495     


Gly Lys Leu Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr 
            500                 505                 510         


Arg Cys Gln Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu 
        515                 520                 525             


Ala Gln Val Gln Leu Asn Val Gln Phe Pro Pro Glu Val Glu Pro Ser 
    530                 535                 540                 


Ser Gln Asp Val Arg Gln Ala Leu Gly Arg Pro Val Leu Leu Arg Cys 
545                 550                 555                 560 


Ser Leu Leu Arg Gly Ser Pro Gln Arg Ile Ala Ser Ala Val Trp Arg 
                565                 570                 575     


Phe Lys Gly Gln Leu Leu Pro Pro Pro Pro Val Val Pro Ala Ala Ala 
            580                 585                 590         


Glu Ala Pro Asp His Ala Glu Leu Arg Leu Asp Ala Val Thr Arg Asp 
        595                 600                 605             


Ser Ser Gly Ser Tyr Glu Cys Ser Val Ser Asn Asp Val Gly Ser Ala 
    610                 615                 620                 


Ala Cys Leu Phe Gln Val Ser Ala Lys Ala Tyr Ser Pro Glu Phe Tyr 
625                 630                 635                 640 


Phe Asp Thr Pro Asn Pro Thr Arg Ser His Lys Leu Ser Lys Asn Tyr 
                645                 650                 655     


Ser Tyr Val Leu Gln Trp Thr Gln Arg Glu Pro Asp Ala Val Asp Pro 
            660                 665                 670         


Val Leu Asn Tyr Arg Leu Ser Ile Arg Gln Leu Asn Gln His Asn Ala 
        675                 680                 685             


Val Val Lys Ala Ile Pro Val Arg Arg Val Glu Lys Gly Gln Leu Leu 
    690                 695                 700                 


Glu Tyr Ile Leu Thr Asp Leu Arg Val Pro His Ser Tyr Glu Val Arg 
705                 710                 715                 720 


Leu Thr Pro Tyr Thr Thr Phe Gly Ala Gly Asp Met Ala Ser Arg Ile 
                725                 730                 735     


Ile His Tyr Thr Glu Pro Ile Asn Ser Pro Asn Leu Ser Asp Asn Thr 
            740                 745                 750         


Cys His Phe Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr 
        755                 760                 765             


Asp Asn Phe Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys 
    770                 775                 780                 


Arg Ser Pro Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu 
785                 790                 795                 800 


Gly Tyr Tyr Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp 
                805                 810                 815     


Arg Ala Arg Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Tyr 
            820                 825                 830         


Cys Val Ser Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu 
        835                 840                 845             


Asn Leu Leu Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala 
    850                 855                 860                 


Trp Ser Leu Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val 
865                 870                 875                 880 


Pro Ile Ser Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg 
                885                 890                 895     


Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys 
            900                 905                 910         


Lys Gly Glu Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Val Val Val 
        915                 920                 925             


Met Pro Gly Ser Gly Ala Pro Cys Gln Ser Ser Pro Gln Leu Trp Gly 
    930                 935                 940                 


Pro Met Ala Ile Phe Leu Leu Ala Leu Gln Arg 
945                 950                 955 


<210>  19

<211>  2868

<212>  DNA

<213>  Homo sapiens



<400>  19
atggaggtga cctgccttct acttctggcg ctgatcccct tccactgccg gggacaagga     60

gtctacgctc cagcccaggc gcagatcgtg catgcgggcc aggcatgtgt ggtgaaagag    120

gacaatatca gcgagcgtgt ctacaccatc cgggaggggg acaccctcat gctgcagtgc    180

cttgtaacag ggcaccctcg accccaggta cggtggacca agacggcagg tagcgcctcg    240

gacaagttcc aggagacatc ggtgttcaac gagacgctgc gcatcgagcg tattgcacgc    300

acgcagggcg gccgctacta ctgcaaggct gagaacggcg tgggggtgcc ggccatcaag    360

tccatccgcg tggacgtgca gtacctggat gagccaatgc tgacggtgca ccagacggtg    420

agcgatgtgc gaggcaactt ctaccaggag aagacggtgt tcctgcgctg tactgtcaac    480

tccaacccac ctgcccgctt catctggaag cggggttccg ataccctatc ccacagccag    540

gacaatgggg ttgacatcta tgagcccctc tacactcagg gggagaccaa ggtcctgaag    600

ctgaagaacc tgcggcccca ggactatgcc agctacacct gccaggtgtc tgtgcgtaac    660

gtgtgcggca tcccagacaa ggccatcacc ttccggctca ccaacaccac ggcaccacca    720

gccctgaagc tgtctgtgaa cgaaactctg gtggtgaacc ctggggagaa tgtgacggtg    780

cagtgtctgc tgacaggcgg tgatcccctc ccccagctgc agtggtccca tgggcctggc    840

ccactgcccc tgggtgctct ggcccagggt ggcaccctca gcatcccttc agtgcaggcc    900

cgggactctg gctactacaa ctgcacagcc accaacaatg tgggcaaccc tgccaagaag    960

actgtcaacc tgctggtgcg atccatgaag aacgctacat tccagatcac tcctgacgtg   1020

atcaaagaga gtgagaacat ccagctgggc caggacctga agctatcgtg ccacgtggat   1080

gcagtgcccc aggagaaggt gacctaccag tggttcaaga atggcaagcc ggcacgcatg   1140

tccaagcggc tgctggtgac ccgcaatgat cctgagctgc ccgcagtcac cagcagccta   1200

gagctcattg acctgcactt cagtgactat ggcacctacc tgtgcatggc ttctttccca   1260

ggggcacccg tgcccgacct cagcgtcgag gtcaacatct cctctgagac agtgccgccc   1320

accatcagtg tgcccaaggg tagggccgtg gtgaccgtgc gcgagggatc gcctgccgag   1380

ctgcaatgcg aggtgcgggg caagccgcgg ccgccagtgc tctggtcccg cgtggacaag   1440

gaggctgcac tgctgccctc ggggctgccc ctggaggaga ctccggacgg gaagctgcgg   1500

ctggagcgag tgagccgaga catgagcggg acctaccgct gccagacggc ccgctataat   1560

ggcttcaacg tgcgcccccg tgaggcccag gtgcagctga acgtgcagtt cccgccggag   1620

gtggagccca gttcccagga cgtgcgccag gcgctgggcc ggcccgtgct cctgcgctgc   1680

tcgctgctgc gaggcagccc ccagcgcatc gcctcggctg tgtggcgttt caaagggcag   1740

ctgctgccgc cgccgcctgt tgttcccgcc gccgccgagg cgccggatca cgcggagctg   1800

cgcctcgacg ccgtaactcg cgacagcagc ggcagctacg agtgcagcgt ctccaacgat   1860

gtgggctcgg ctgcctgcct cttccaggtc tccgccaaag cctacagccc ggagttttac   1920

ttcgacaccc ccaaccccac ccgcagccac aagctgtcca agaactactc ctacgtgctg   1980

cagtggactc agagggagcc cgacgctgtc gaccctgtgc tcaactacag actcagcatc   2040

cgccagttga accagcacaa tgcggtggtc aaggccatcc cggtccggcg tgtggagaag   2100

gggcagctgc tggagtacat cctgaccgat ctccgtgtgc cccacagcta tgaggtccgc   2160

ctcacaccct ataccacctt cggggctggt gacatggcct cccgcatcat ccactacaca   2220

gagcccatca actctccgaa cctttcagac aacacctgcc actttgagga tgagaagatc   2280

tgtggctata cccaggacct gacagacaac tttgactgga cgcggcagaa tgccctcacc   2340

cagaacccca aacgctcccc caacactggt ccccccaccg acataagtgg cacccctgag   2400

ggctactaca tgttcatcga gacatcgagg cctcgggagc tgggggaccg tgcaaggtta   2460

gtgagtcccc tctacaatgc cagcgccaag ttctactgtg tctccttctt ctaccacatg   2520

tacgggaaac acatcggctc cctcaacctc ctggtgcggt cccggaacaa aggggctctg   2580

gacacgcacg cctggtctct cagtggcaat aagggcaatg tgtggcagca ggcccatgtg   2640

cccatcagcc ccagtgggcc cttccagatt atttttgagg gggttcgagg cccgggctac   2700

ctgggggata ttgccataga tgacgtcaca ctgaagaagg gggagtgtcc ccggaagcag   2760

acggatccca ataaagtggt ggtgatgccg ggcagtggag ccccctgcca gtccagccca   2820

cagctgtggg ggcccatggc catcttcctc ttggcgttgc agagatga                2868


<210>  20

<211>  880

<212>  PRT

<213>  Homo sapiens



<400>  20

Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala Gly Gln 
1               5                   10                  15      


Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr Thr Ile 
            20                  25                  30          


Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly His Pro 
        35                  40                  45              


Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys 
    50                  55                  60                  


Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile 
65                  70                  75                  80  


Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn Gly Val 
                85                  90                  95      


Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr Leu Asp 
            100                 105                 110         


Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg Gly Asn 
        115                 120                 125             


Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser Asn 
    130                 135                 140                 


Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser His 
145                 150                 155                 160 


Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln Gly 
                165                 170                 175     


Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr Ala 
            180                 185                 190         


Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile Pro Asp 
        195                 200                 205             


Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro Ala Leu 
    210                 215                 220                 


Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu Asn Val 
225                 230                 235                 240 


Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln Leu Gln 
                245                 250                 255     


Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala Gln Gly 
            260                 265                 270         


Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly Tyr Tyr 
        275                 280                 285             


Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys Thr Val 
    290                 295                 300                 


Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile Thr Pro 
305                 310                 315                 320 


Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp Leu Lys 
                325                 330                 335     


Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr Tyr Gln 
            340                 345                 350         


Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu Leu Val 
        355                 360                 365             


Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu Glu Leu 
    370                 375                 380                 


Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met Ala Ser 
385                 390                 395                 400 


Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn Ile Ser 
                405                 410                 415     


Ser Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg Ala Val 
            420                 425                 430         


Val Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu Val Arg 
        435                 440                 445             


Gly Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys Glu Ala 
    450                 455                 460                 


Ala Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp Gly Lys 
465                 470                 475                 480 


Leu Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr Arg Cys 
                485                 490                 495     


Gln Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu Ala Gln 
            500                 505                 510         


Val Gln Leu Asn Val Gln Phe Pro Pro Glu Val Glu Pro Ser Ser Gln 
        515                 520                 525             


Asp Val Arg Gln Ala Leu Gly Arg Pro Val Leu Leu Arg Cys Ser Leu 
    530                 535                 540                 


Leu Arg Gly Ser Pro Gln Arg Ile Ala Ser Ala Val Trp Arg Phe Lys 
545                 550                 555                 560 


Gly Gln Leu Leu Pro Pro Pro Pro Val Val Pro Ala Ala Ala Glu Ala 
                565                 570                 575     


Pro Asp His Ala Glu Leu Arg Leu Asp Ala Val Thr Arg Asp Ser Ser 
            580                 585                 590         


Gly Ser Tyr Glu Cys Ser Val Ser Asn Asp Val Gly Ser Ala Ala Cys 
        595                 600                 605             


Leu Phe Gln Val Ser Ala Lys Ala Tyr Ser Pro Glu Phe Tyr Phe Asp 
    610                 615                 620                 


Thr Pro Asn Pro Thr Arg Ser His Lys Leu Ser Lys Asn Tyr Ser Tyr 
625                 630                 635                 640 


Val Leu Gln Trp Thr Gln Arg Glu Pro Asp Ala Val Asp Pro Val Leu 
                645                 650                 655     


Asn Tyr Arg Leu Ser Ile Arg Gln Leu Asn Gln His Asn Ala Val Val 
            660                 665                 670         


Lys Ala Ile Pro Val Arg Arg Val Glu Lys Gly Gln Leu Leu Glu Tyr 
        675                 680                 685             


Ile Leu Thr Asp Leu Arg Val Pro His Ser Tyr Glu Val Arg Leu Thr 
    690                 695                 700                 


Pro Tyr Thr Thr Phe Gly Ala Gly Asp Met Ala Ser Arg Ile Ile His 
705                 710                 715                 720 


Tyr Thr Glu Pro Ile Asn Ser Pro Asn Leu Ser Asp Asn Thr Cys His 
                725                 730                 735     


Phe Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr Asp Asn 
            740                 745                 750         


Phe Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys Arg Ser 
        755                 760                 765             


Pro Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu Gly Tyr 
    770                 775                 780                 


Tyr Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp Arg Ala 
785                 790                 795                 800 


Arg Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Gln Ile Ile 
                805                 810                 815     


Phe Glu Gly Val Arg Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile Asp 
            820                 825                 830         


Asp Val Thr Leu Lys Lys Gly Glu Cys Pro Arg Lys Gln Thr Asp Pro 
        835                 840                 845             


Asn Lys Val Val Val Met Pro Gly Ser Gly Ala Pro Cys Gln Ser Ser 
    850                 855                 860                 


Pro Gln Leu Trp Gly Pro Met Ala Ile Phe Leu Leu Ala Leu Gln Arg 
865                 870                 875                 880 


<210>  21

<211>  58

<212>  PRT

<213>  Homo sapiens



<400>  21

Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly His Pro Arg Pro 
1               5                   10                  15      


Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys Phe Gln 
            20                  25                  30          


Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile Ala Arg 
        35                  40                  45              


Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala 
    50                  55              


<210>  22

<211>  67

<212>  PRT

<213>  Homo sapiens



<400>  22

Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn Ser Asn Pro Pro Ala 
1               5                   10                  15      


Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu Ser His Ser Gln Asp 
            20                  25                  30          


Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr Gln Gly Glu Thr Lys 
        35                  40                  45              


Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp Tyr Ala Ser Tyr Thr 
    50                  55                  60                  


Cys Gln Val 
65          


<210>  23

<211>  56

<212>  PRT

<213>  Homo sapiens



<400>  23

Gly Glu Asn Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu 
1               5                   10                  15      


Pro Gln Leu Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala 
            20                  25                  30          


Leu Ala Gln Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp 
        35                  40                  45              


Ser Gly Tyr Tyr Asn Cys Thr Ala 
    50                  55      


<210>  24

<211>  68

<212>  PRT

<213>  Homo sapiens



<400>  24

Gly Gln Asp Leu Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu 
1               5                   10                  15      


Lys Val Thr Tyr Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser 
            20                  25                  30          


Lys Arg Leu Leu Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr 
        35                  40                  45              


Ser Ser Leu Glu Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr 
    50                  55                  60                  


Leu Cys Met Ala 
65              


<210>  25

<211>  61

<212>  PRT

<213>  Homo sapiens



<400>  25

Gly Ser Pro Ala Glu Leu Gln Cys Glu Val Arg Gly Lys Pro Arg Pro 
1               5                   10                  15      


Pro Val Leu Trp Ser Arg Val Asp Lys Glu Ala Ala Leu Leu Pro Ser 
            20                  25                  30          


Gly Leu Pro Leu Glu Glu Thr Pro Asp Gly Lys Leu Arg Leu Glu Arg 
        35                  40                  45              


Val Ser Arg Asp Met Ser Gly Thr Tyr Arg Cys Gln Thr 
    50                  55                  60      


<210>  26

<211>  65

<212>  PRT

<213>  Homo sapiens



<400>  26

Gly Arg Pro Val Leu Leu Arg Cys Ser Leu Leu Arg Gly Ser Pro Gln 
1               5                   10                  15      


Arg Ile Ala Ser Ala Val Trp Arg Phe Lys Gly Gln Leu Leu Pro Pro 
            20                  25                  30          


Pro Pro Val Val Pro Ala Ala Ala Glu Ala Pro Asp His Ala Glu Leu 
        35                  40                  45              


Arg Leu Asp Ala Val Thr Arg Asp Ser Ser Gly Ser Tyr Glu Cys Ser 
    50                  55                  60                  


Val 
65  


<210>  27

<211>  91

<212>  PRT

<213>  Homo sapiens



<400>  27

Thr Pro Asn Pro Thr Arg Ser His Lys Leu Ser Lys Asn Tyr Ser Tyr 
1               5                   10                  15      


Val Leu Gln Trp Thr Gln Arg Glu Pro Asp Ala Val Asp Pro Val Leu 
            20                  25                  30          


Asn Tyr Arg Leu Ser Ile Arg Gln Leu Asn Gln Leu Asn Gln His Gln 
        35                  40                  45              


Ala Val Val Lys Ala Ile Pro Val Arg Arg Val Gln Lys Gly Gln Leu 
    50                  55                  60                  


Leu Glu Tyr Ile Leu Thr Asp Leu Arg Val Pro His Ser Glu Val Arg 
65                  70                  75                  80  


Leu Thr Pro Tyr Thr Thr Phe Gly Asp Met Ala 
                85                  90      


<210>  28

<211>  75

<212>  PRT

<213>  Homo sapiens



<400>  28

Cys Gly Tyr Thr Gln Asp Leu Thr Asp Asn Phe Asp Trp Thr Arg Gln 
1               5                   10                  15      


Asn Ala Leu Thr Gln Asn Pro Lys Arg Ser Pro Asn Thr Gly Pro Pro 
            20                  25                  30          


Thr Asp Ile Ser Gly Thr Pro Glu Gly Tyr Tyr Met Phe Ile Glu Thr 
        35                  40                  45              


Ser Arg Pro Arg Glu Leu Gly Asp Arg Ala Arg Leu Val Ser Pro Leu 
    50                  55                  60                  


Tyr Asn Ala Ser Ala Lys Phe Tyr Cys Val Ser 
65                  70                  75  


<210>  29

<211>  166

<212>  PRT

<213>  Homo sapiens



<400>  29

Cys His Phe Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr 
1               5                   10                  15      


Asp Asn Phe Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys 
            20                  25                  30          


Arg Ser Pro Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu 
        35                  40                  45              


Gly Tyr Tyr Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp 
    50                  55                  60                  


Arg Ala Arg Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Tyr 
65                  70                  75                  80  


Cys Val Ser Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu 
                85                  90                  95      


Asn Leu Leu Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala 
            100                 105                 110         


Trp Ser Leu Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val 
        115                 120                 125             


Pro Ile Ser Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg 
    130                 135                 140                 


Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys 
145                 150                 155                 160 


Lys Gly Glu Cys Pro Arg 
                165     


<210>  30

<211>  273

<212>  PRT

<213>  Homo sapiens



<400>  30

Leu Asn Gln His Asn Ala Val Val Lys Ala Ile Pro Val Arg Arg Val 
1               5                   10                  15      


Glu Lys Gly Gln Leu Leu Glu Tyr Ile Leu Thr Asp Leu Arg Val Pro 
            20                  25                  30          


His Ser Tyr Glu Val Arg Leu Thr Pro Tyr Thr Thr Phe Gly Ala Gly 
        35                  40                  45              


Asp Met Ala Ser Arg Ile Ile His Tyr Thr Glu Pro Ile Asn Ser Pro 
    50                  55                  60                  


Asn Leu Ser Asp Asn Thr Cys His Phe Glu Asp Glu Lys Ile Cys Gly 
65                  70                  75                  80  


Tyr Thr Gln Asp Leu Thr Asp Asn Phe Asp Trp Thr Arg Gln Asn Ala 
                85                  90                  95      


Leu Thr Gln Asn Pro Lys Arg Ser Pro Asn Thr Gly Pro Pro Thr Asp 
            100                 105                 110         


Ile Ser Gly Thr Pro Glu Gly Tyr Tyr Met Phe Ile Glu Thr Ser Arg 
        115                 120                 125             


Pro Arg Glu Leu Gly Asp Arg Ala Arg Leu Val Ser Pro Leu Tyr Asn 
    130                 135                 140                 


Ala Ser Ala Lys Phe Tyr Cys Val Ser Phe Phe Tyr His Met Tyr Gly 
145                 150                 155                 160 


Lys His Ile Gly Ser Leu Asn Leu Leu Val Arg Ser Arg Asn Lys Gly 
                165                 170                 175     


Ala Leu Asp Thr His Ala Trp Ser Leu Ser Gly Asn Lys Gly Asn Val 
            180                 185                 190         


Trp Gln Gln Ala His Val Pro Ile Ser Pro Ser Gly Pro Phe Gln Ile 
        195                 200                 205             


Ile Phe Glu Gly Val Arg Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile 
    210                 215                 220                 


Asp Asp Val Thr Leu Lys Lys Gly Glu Cys Pro Arg Lys Gln Thr Asp 
225                 230                 235                 240 


Pro Asn Lys Val Val Val Met Pro Gly Ser Gly Ala Pro Cys Gln Ser 
                245                 250                 255     


Ser Pro Gln Leu Trp Gly Pro Met Ala Ile Phe Leu Leu Ala Leu Gln 
            260                 265                 270         


Arg 
    


<210>  31

<211>  955

<212>  PRT

<213>  Homo sapiens



<400>  31

Met Glu Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys 
1               5                   10                  15      


Arg Gly Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala 
            20                  25                  30          


Gly Gln Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr 
        35                  40                  45              


Thr Ile Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly 
    50                  55                  60                  


His Pro Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser 
65                  70                  75                  80  


Asp Lys Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu 
                85                  90                  95      


Arg Ile Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn 
            100                 105                 110         


Gly Val Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr 
        115                 120                 125             


Leu Asp Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg 
    130                 135                 140                 


Gly Asn Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn 
145                 150                 155                 160 


Ser Asn Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu 
                165                 170                 175     


Ser His Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr 
            180                 185                 190         


Gln Gly Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp 
        195                 200                 205             


Tyr Ala Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile 
    210                 215                 220                 


Pro Asp Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro 
225                 230                 235                 240 


Ala Leu Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu 
                245                 250                 255     


Asn Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln 
            260                 265                 270         


Leu Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala 
        275                 280                 285             


Gln Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly 
    290                 295                 300                 


Tyr Tyr Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys 
305                 310                 315                 320 


Thr Val Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile 
                325                 330                 335     


Thr Pro Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp 
            340                 345                 350         


Leu Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr 
        355                 360                 365             


Tyr Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu 
    370                 375                 380                 


Leu Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu 
385                 390                 395                 400 


Glu Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met 
                405                 410                 415     


Ala Ser Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn 
            420                 425                 430         


Ile Ser Ser Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg 
        435                 440                 445             


Ala Val Val Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu 
    450                 455                 460                 


Val Arg Gly Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys 
465                 470                 475                 480 


Glu Ala Ala Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp 
                485                 490                 495     


Gly Lys Leu Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr 
            500                 505                 510         


Arg Cys Gln Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu 
        515                 520                 525             


Ala Gln Val Gln Leu Asn Val Gln Phe Pro Pro Glu Val Glu Pro Ser 
    530                 535                 540                 


Ser Gln Asp Val Arg Gln Ala Leu Gly Arg Pro Val Leu Leu Arg Cys 
545                 550                 555                 560 


Ser Leu Leu Arg Gly Ser Pro Gln Arg Ile Ala Ser Ala Val Trp Arg 
                565                 570                 575     


Phe Lys Gly Gln Leu Leu Pro Pro Pro Pro Val Val Pro Ala Ala Ala 
            580                 585                 590         


Glu Ala Pro Asp His Ala Glu Leu Arg Leu Asp Ala Val Thr Arg Asp 
        595                 600                 605             


Ser Ser Gly Ser Tyr Glu Cys Ser Val Ser Asn Asp Val Gly Ser Ala 
    610                 615                 620                 


Ala Cys Leu Phe Gln Val Ser Ala Lys Ala Tyr Ser Pro Glu Phe Tyr 
625                 630                 635                 640 


Phe Asp Thr Pro Asn Pro Thr Arg Ser His Lys Leu Ser Lys Asn Tyr 
                645                 650                 655     


Ser Tyr Val Leu Gln Trp Thr Gln Arg Glu Pro Asp Ala Val Asp Pro 
            660                 665                 670         


Val Leu Asn Tyr Arg Leu Ser Ile Arg Gln Leu Asn Gln His Asn Ala 
        675                 680                 685             


Val Val Lys Ala Ile Pro Val Arg Arg Val Glu Lys Gly Gln Leu Leu 
    690                 695                 700                 


Glu Tyr Ile Leu Thr Asp Leu Arg Val Pro His Ser Tyr Glu Val Arg 
705                 710                 715                 720 


Leu Thr Pro Tyr Thr Thr Phe Gly Ala Gly Asp Met Ala Ser Arg Ile 
                725                 730                 735     


Ile His Tyr Thr Glu Pro Ile Asn Ser Pro Asn Leu Ser Asp Asn Thr 
            740                 745                 750         


Cys His Phe Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr 
        755                 760                 765             


Asp Asn Phe Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys 
    770                 775                 780                 


Arg Ser Pro Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu 
785                 790                 795                 800 


Gly Tyr Tyr Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp 
                805                 810                 815     


Arg Ala Arg Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Tyr 
            820                 825                 830         


Cys Val Ser Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu 
        835                 840                 845             


Asn Leu Leu Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala 
    850                 855                 860                 


Trp Ser Leu Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val 
865                 870                 875                 880 


Pro Ile Ser Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg 
                885                 890                 895     


Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys 
            900                 905                 910         


Lys Gly Glu Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Val Val Val 
        915                 920                 925             


Met Pro Gly Ser Gly Ala Pro Cys Gln Ser Ser Pro Gln Leu Trp Gly 
    930                 935                 940                 


Pro Met Ala Ile Phe Leu Leu Ala Leu Gln Arg 
945                 950                 955 


